Clinical case report of intrahepatic cholestasis of pregnancy

Authors

  • Grace Pamela López Pérez Universidad Técnica de Ambato - Ecuador
  • Verónica Sofia Quenorán Almeida Universidad Técnica de Ambato - Ecuador
  • Yolanda Elizabeth López Romo Universidad Técnica de Ambato - Ecuador
  • Marlene Elizabeth Cumbajin Montatixe Universidad Técnica de Ambato - Ecuador

DOI:

https://doi.org/10.51798/sijis.v3i2.344

Keywords:

Intrahepatic cholestasis. Pregnancy. Pruritus. Elevated bile acids

Abstract

Introduction: Gestational Intrahepatic Cholestasis (GIC), is considered a dangerous pathology for the fetus, leading to termination of pregnancy, with a high incidence of intrauterine fetal death. Timely treatment reduces symptoms and avoids fetal death. Objective: To compare the signs and symptoms presented in the case report with those presented in the literature review, determining the complications that the fetus may have. Methodology: The methodology used for the analysis of the study comprises a descriptive, comparative design, information was collected by reviewing the patient's clinical history. Results: Based on the analysis, several authors agree that IGC is a condition mainly associated to genetics, not very recurrent, which appears during pregnancy and disappears when it ends, its main symptoms are pruritus in the palms of the hands and feet, in addition to the elevation of bile acids. With a considerable affection towards the fetus and without any subsequent complication for the mother. The pharmacological treatment recommended and used is Ursodeoxycholic. Conclusion: IGC is a complex and potentially dangerous pathology, which compromises maternal-fetal health, and to this day it is still debatable and shows the diversity of criteria to deal with it.

Author Biographies

Grace Pamela López Pérez , Universidad Técnica de Ambato - Ecuador

Universidad Técnica de Ambato - Ecuador

Verónica Sofia Quenorán Almeida , Universidad Técnica de Ambato - Ecuador

Universidad Técnica de Ambato - Ecuador

Yolanda Elizabeth López Romo, Universidad Técnica de Ambato - Ecuador

Universidad Técnica de Ambato - Ecuador

Marlene Elizabeth Cumbajin Montatixe, Universidad Técnica de Ambato - Ecuador

Universidad Técnica de Ambato - Ecuador

References

Almeida, L., Vásquez, I., López, M., García, L., & Forns, X. (2020). Colestasis Intrahepática Gestacional. Hospital Clínic | Hospital Sant Joan de Déu | Universitat de Barcelona. https://medicinafetalbarcelona.org/protocolos/es/patologia-materna-obstetrica/colestasis%20intrahep%C3%A1tica.pdf

American Liver Foundation. (2021). Colestasis intrahepática del embarazo (ICP) [American Liver Foundation]. American Liver Foundation. https://liverfoundation.org/es/for-patients/about-the-liver/diseases-of-the-liver/intrahepatic-cholestasis-of-pregnancy/

Arriaga, A., Rosales, L., Martínez, L., Pérez, Y., Jiménez, S., Marcial, A., Villa, R., Chaucanés, A., & Palma, L. (2021). Colestasis intrahepática del embarazo Un reto más para la obstetricia. Revista de la Facultad de Medicina (México), 64(3), 20-36. https://doi.org/10.22201/fm.24484865e.2021.64.3.03

Ayusso, E. (s. f.). Colestasis Intrahepática Gestacional. IBC LABORATORIOS. Recuperado 25 de abril de 2022, de https://www.ibcrosario.com.ar/articulos/Colestasis-Intrahepatica-Gestacional.html

Ceriani, J. (2018). The limits of viability in preterm infants, a growing ethical dilemma. Arch Argent Pediatr, 116(3), 170-171. https://doi.org/10.5546/aap.2018.eng.170

Dorelo, R., Chiodi, D., Sánchez, A., & Hernández, N. (s. f.). Intrahepatic cholestasis of pregnancy: Early presentation and relationship with infection by the hepatitis c virus. Case reports. Facultad de Medicina, Universidad de la República. Montevideo, Uruguay, 8(2), e403. https://doi.org/10.25184/anfamed2021v8n2a11

Espinoza, A., Vílchez, M., & Webb, K. (2019). Colestasis intrahepática del embarazo. Revista Medica Sinergia, 4(6), 14-23. https://doi.org/10.31434/rms.v4i6.196

Ferreiro, J., Lauría, W., & Rey, G. (2020). Nuevas miradas en la colestasis Intrahepática del embarazo. Revisión bibliográfica. Archivos de Ginecología y Obstetricia, 58(3), 177-190. https://ago.uy/descargar/adjunto/61-u9uwxe-ago58-3-art-2.pdf

Gallardo, J., Lemionet, D., Acevedo, S., Velázquez, B., Ramírez, J., & Camarena, D. (2018). Resultados perinatales adversos en colestasis intrahepática del embarazo. Perinatología y Reproducción Humana, 32(3), 131-137. https://doi.org/10.1016/j.rprh.2018.08.002

Hoofnagle, J., & Björnsson, E. S. (2019). Drug-Induced Liver Injury—Types and Phenotypes. New England Journal of Medicine, 381(3), 264-273. https://doi.org/10.1056/NEJMra1816149

MayoClinic. (2020). Colestasis del embarazo. MayoClinic. https://www.mayoclinic.org/es-es/diseases-conditions/cholestasis-of-pregnancy/diagnosis-treatment/drc-20363258

Murillo, M., Jiménez, S., & Kagi, M. (2020). Colestasis intrahepática del embarazo. Revista Médica Sinergia, 5(11), e600-e600. https://doi.org/10.31434/rms.v5i11.600

Ng Ye, L. Y., Castro, G., Aragón, P., Álvarez, G., & Rojas, E. (2021). Colestasis Intrahepática del Embarazo. Revista de la Facultad de Medicina de la Universidad de lberoamérica, 3(2), Article 2. https://doi.org/10.54376/rcmui.v3i2.59

Peraza, M., & Borbón, J. (2021). Colestasis Intrahepatica del Embarazo: Revisión de tema. Revista Ciencia y Salud Integrando Conocimientos, 5(6), 7-15. https://doi.org/10.34192/cienciaysalud.v5i6.320

Pescador, M., Zeballos, S., Ramos, C., & Sánchez, M. (2021). Límite de Viabilidad: ¿Dónde estamos y hacia dónde vamos? Revista Médica Clínica Las Condes, 32(6), 656-663. https://doi.org/10.1016/j.rmclc.2021.10.002

Piechota, J., & Jelski, W. (2020). Intrahepatic Cholestasis in Pregnancy: Review of the Literature. Journal of Clinical Medicine, 9(5), 1361. https://doi.org/10.3390/jcm9051361

Pizarro, M., Guerrero, C., & Chacón, N. (2022). Colestasis intrahepática del embarazo: Una revisión sistemática. Revista Medica Sinergia, 7(3), e771-e771. https://doi.org/10.31434/rms.v7i3.771

Riethmuller, D., Equy, V., & Mottet, N. (2022). Distocia dinámica. EMC - Ginecología-Obstetricia, 58(1), 1-11. https://doi.org/10.1016/S1283-081X(22)46054-1

Ruiz, J., García de la Filia, I., Burgos, D., & Martín, R. (2020). Estudio de la alteración de las pruebas de función hepática en el embarazo. Medicine, 13(4), 230-234.

Stanojevic, M. (2021). Limits Of Viability: Should We Play God? Psychiatria Danubina, 33(3), S280-S291. https://hrcak.srce.hr/file/374387

Tessore, I., Pacheco, A., & Zamory, E. (s. f.). Colestasis Intrahepática del Embarazo: Asociación entre Factores de Riesgo y Elevación de Ácidos Biliares. BIOQUINFORMA DIGITAL, 1(4). https://cobico.com.ar/wp-content/archivos/2022/01/PG-COLESTASIS-INTRAHEP%C3%81TICA-DEL-EMBARAZO-ASOCIACI%C3%93N-ENTRE.pdf

Toro, L., Correa, E., Calle, L., Ocampo, A., & Vélez, S. (2019). Enfermedades hepáticas y embarazo. Rev Colomb Gastroenterol, 34(4), 385-398. https://doi.org/10.22516/25007440.367

Yanque, O. (2020). Colestasis Intrahepática gestacional. Revista Peruana de Investigación en Salud, 4(1), 37-42. https://doi.org/10.35839/repis.4.1.608

Published

2022-05-14

How to Cite

López Pérez , G. P. ., Quenorán Almeida , V. S. ., López Romo, Y. E. ., & Cumbajin Montatixe, M. E. . (2022). Clinical case report of intrahepatic cholestasis of pregnancy. Sapienza: International Journal of Interdisciplinary Studies, 3(2), 362–372. https://doi.org/10.51798/sijis.v3i2.344

Issue

Section

Continuous flow- Articles, Essays, Professional Case Studies